Abstract
Atopic dermatitis is characterized by skin barrier dysfunction, edema, and infiltration with various inflammatory cells. Horse oil,the purified form from horse fat, has been used for a long time by fork remedies on burn, wound, and various skin diseases. Inthis study, we investigated the improving effects of horse oil on atopic dermatitis induced by 0.3% of DNCB in mice. Horse oil B(oil phase, 100 mg/kg) significantly decreased serum IgE levels in experimental atopic dermatitis mice induced by DNCB. Also,horse oil A (cream phase, 100 mg/kg) and B alleviates atopic dermatitis symptoms (ear edema, inflammatory cell infiltration, andlymph node size). Overall, the effect of horse oil B was slightly better. These results suggest that horse oil can be a usefulremedy to improve atopic dermatitis.
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