Abstract
The aim of this study was to investigate the amount of external apical root resorption (EARR) and the release of interleukin (IL)-6 in the gingival crevicular fluid (GCF) in subjects treated with a low-force low-friction system. Sixty patients were assigned to two groups of thirty patients for each: one group received treatment with self-ligating brackets and the other with conventional ligated edgewise brackets. All patients were treated with extraction of the maxillary first premolars. The EARR of the maxillary central incisors was evaluated on the periapical radiographs and cephalograms, taken before and after orthodontic treatment. The GCF was also collected non-invasively from the mesial and distal sides of central incisors by using filter paper strips before and after orthodontic treatment. Enzyme-linked immunosorbent assay (ELISA) kits were used to determine the IL-6 levels in the GCF samples. A significant difference was found in the amount of EARR between the patients with self-ligating brackets and conventional brackets. The mean amount of EARR was significantly lower for self-ligating brackets than conventional brackets (p < 0.05). The GCF levels of IL-6 for the patients with self-ligating brackets appliance were significantly lower than for those with the conventional brackets (p < 0.05). These results show that the mean amount of EARR and the GCF levels of IL-6 were significantly lower in the patients treated using low-force low-friction appliances than conventional brackets. Therefore, self-ligating brackets may be a useful system for reducing inflammation and EARR.
Highlights
External apical root resorption (EARR) is an unavoidable pathological consequence of orthodontic tooth movement
The aim of this study was to investigate the amount of external apical root resorption (EARR) and the release of interleukin (IL)-6 in the gingival crevicular fluid (GCF) in subjects treated with a low-force lowfriction system
The GCF levels of IL-6 for the patients with self-ligating brackets appliance were significantly lower than for those with the conventional brackets (p < 0.05). These results show that the mean amount of EARR and the GCF levels of IL-6 were significantly lower in the patients treated using low-force low-friction appliances than conventional brackets
Summary
External apical root resorption (EARR) is an unavoidable pathological consequence of orthodontic tooth movement. It can be defined as an iatrogenic disorder that unpredictably occurs after orthodontic treatment, whereby the resorbed apical root portion is replaced with normal bone. EARR is a sterile inflammatory process that is extremely complex, and involves various disparate components, including mechanical forces, tooth and bone, cells, the surrounding matrix, and certain known biologic messengers [1,2]. Interleukin-6 (IL-6) is a potent stimulus for bone resorption and osteoclastic cell recruitment during orthodontic tooth movement [3,4]. With regard to the relationship between EARR and IL-6, Hayashi et al indicated that IL-6 is important for the induction and further processing of mechanically-induced root resorption in the rat [5]. IL-6 may contribute to EARR during orthodontic tooth movement
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