Abstract
Objective: To reconnoiter the IL-1A (-889) and IL-1RN (+2018) gene polymorphisms and their association with EARR . Material and Methods: The Science Direct, PubMed and Scopus databases were comprehensively searched by two independent reviewers. In addition, the bibliographies of all relevant publications and textbooks were searched manually. A meta-analysis was performed using data available up to May 9, 2020. Results: A total of 13 and 9 publications were selected for the systematic review and meta-analysis, respectively for both IL-1A and IL-1RN genes. Odds ratio (OR) was used to evaluate the association of the gene polymorphism and the risk of EARR. The risk of EARR was estimated using the overall OR from the published studies. No association was found for IL-1A gene for the risk of EARR. However, the dominant and co-dominant models of IL-1RN gene polymorphism were associated with the risk of EARR . Conclusion: More studies are warranted to determine the relationship between IL-1A and IL-1RN gene polymorphisms and EARR for a clearer understanding of their interactions.
Highlights
External apical root resorption (EARR) is a shortening of the root apex, which can be acquired due to various mechanical and/or genetic factors [1]
Discarding duplicates, 7 publications were selected for the IL-1A gene [1,2,3,7,16,17,18] and 6 publications were chosen for IL-1 receptor antagonist (IL-1RN) gene [2,3,8,10,18,19] to be included in this systematic review (Table 1)
From 13 publications initially chosen for the systematic review for both IL-1A and IL-1RN genes, only 9 publications were selected for quality assessment due to overlapping of the gene studied
Summary
External apical root resorption (EARR) is a shortening of the root apex, which can be acquired due to various mechanical and/or genetic factors [1]. Several studies have been conducted to determine the genetic association and the orthodontic-induced EARR in various populations [1,2,3,4]. Most of the studies focused on different polymorphisms in interleukins (ILs), Vitamin D receptor (VDR), Tumour Necrosis Factor-alpha (TNF-α), and Cluster of Differentiation (CD) genes to establish their association with EARR in certain populations [5]. Previously reported investigations were mainly focused on the association of IL1A, IL-1B and/or IL-1RN genes with EARR during orthodontic treatments [7,8,9]. Al-Qawasmi et al [1] showed the association between single nucleotide polymorphisms (SNPs) of IL-1A (-889) and IL-1B (+3954) gene polymorphisms and the EARR among the Caucasians in America.
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