Abstract
Diabetes mellitus develops either due to insufficient insulin secretion or lack of insulin resulting from damaged pancreas beta cells. Dyslipidaemia is an acute complication in diabetes mellitus. The aim of this study was to investigate the extenuating effects of T. cattapa leaves and P. americana seed aqueous extracts on streptozotocin-induced lipids profile perturbation and pancreatic damage in experimental rats. Thirty male albino rats were randomly divided into six groups (n = 5). Group 1: (negative control), group 2: 80 mg/kgbwt streptozotocin (positive control), group 3: (80 mg/kgbwt streptozotocin + 200 mg/kgbwt T. catappa leave extract), group 4: (80 mg/kgbwt streptozotocin + 200 mg/kgbwt Persea americana seed extract), group 5: (80 mg/kgbwt streptozotocin + 200 mg/kgbwt extracts-mixture), group 6: (80 mg/kgbwt streptozotocin + 5 mg/kgbwt glibenclamide (standard drug). A single dose of streptozotocin was administered to the rats intraperitoneally; the extracts and glibenclamide were administered orally for 21 days, after which their pancreas was excised for histology. Thereafter, extracts of T. catappa leaves and P. americana seed on serum lipid levels imbalance in streptozotocin-induced diabetic rats were investigated. Histological studies showed a degenerative effect of the pancreatic islet cells of strotozotocin-induced groups. Results showed improvement in the regulation of lipid metabolism as well as the regeneration of the beta cells of pancreas on treatment with T. catappa leaves and P. americana seed. The extracts both equally exert significant antidyslipidemic effects in diabetic rats, in view of the extenuating effects of the extracts on pancreatic islet cells.
Highlights
Diabetes mellitus is regarded as a group of metabolic disorders classified into four broad categories: type 1, type 2, gestational diabetes, and "other specific types.” This disorder has been a challenge to individual’s health and lifestyle (Anthony et al, 2008)
Dyslipidemia is described as high levels of lipids carried by lipoproteins in the blood, which in-turn predisposes to cardiovascular diseases (Miller, 2009)
This present study was carried out to examine the extenuating effects of Terminalia catappa (Indian almond) leave and Persea americana seed aqueous extracts on serum lipid profile perturbation and pancreatic damage associated with streptozotocin-induced diabetes in male wistar rats
Summary
Diabetes mellitus is regarded as a group of metabolic disorders classified into four broad categories: type 1, type 2, gestational diabetes, and "other specific types.” This disorder has been a challenge to individual’s health and lifestyle (Anthony et al, 2008). Diabetes mellitus is regarded as a group of metabolic disorders classified into four broad categories: type 1, type 2, gestational diabetes, and "other specific types.”. This disorder has been a challenge to individual’s health and lifestyle (Anthony et al, 2008). The usual indications of long-term or untreated diabetes may include weight loss, polyuria, polydipsia, and polyphagia (El-Wakf et al, 2011; Adeyi et al, 2015). Serious long-term complications include cardiovascular disease, stroke, chronic kidney disease, foot ulcers, and sever damage to the eyes. Type 1 diabetes mellitus (DM) is often managed with insulin injections. The consumption of lipid-lowering medications may bring about some adverse effects (Hosseini and Hosseinzadeh, 2015); some oral medications can cause low blood sugar (Jelodar et al, 2007; Yadav et al, 2008), and some must be carefully used during pregnancies
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