Abstract
Equilibrium solubility of sickle hemoglobin, partially liganded with CO, is linearly dependent upon initial ligation. Polymer concentration in the initial solution is proportional to the difference between initial concentration and solubility while the polymer volume fraction is proportional to the ratio of these parameters. Such relationships afford a means by which the extent of polymerization and fractional polymer volume in solutions, as well as in intact erythrocytes, may be calculated. Both polymer concentration and volume fraction are independent of degree of ligation and are characteristic of sickle hemoglobin polymer under a variety of conditions. Additionally, the concentration of liganded hemoglobin is enriched in the supernatant (monomer) and diminished in the pellet (polymer), relative to the initial degree of ligation.
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