Abstract
Extensively Drug-Resistant<i>Mycobacterium tuberculosis</i>, India
Highlights
multidrug-resistant TB (MDR TB) cases threaten the effectiveness of chemotherapy for both treatment and control of TB and require the use of second-line drugs that are more expensive, toxic, and less effective than first-line anti-TB drugs (3)
XDR TB is defined as TB caused by a Mycobacterium tuberculosis strain that is resistant to at least rifampin and isoniazid among the first-line anti-TB drugs (MDR TB) in addition to resistance to any fluoroquinolones and at least 1 of 3 injectable second-line drugs (5)
The susceptibility of MDR TB isolates against second-line drugs was done by the absolute concentration method (MIC) for ofloxacin (0.5–16 μg/mL) and kanamycin (2–64 μg/mL) and by 1% proportional sensitivity method for ethionamide (40 μg/mL), p-amino salicylic acid (0.5 μg/ml), clarithromycin (2 μg/mL), and capreomycin (40 μg/mL)
Summary
MDR TB cases threaten the effectiveness of chemotherapy for both treatment and control of TB and require the use of second-line drugs that are more expensive, toxic, and less effective than first-line anti-TB drugs (3). XDR TB is defined as TB caused by a Mycobacterium tuberculosis strain that is resistant to at least rifampin and isoniazid among the first-line anti-TB drugs (MDR TB) in addition to resistance to any fluoroquinolones and at least 1 of 3 injectable second-line drugs (5).
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