Abstract
We report a rare case of cuniculatum carcinoma in a 66-year-old woman with feoderma. She attended the oral medicine service presenting with a deep extensive lesion in the left jugal mucosa, which was symptomatic, hardened with irregular edges, and reddish and had ulcerated areas, measuring approximately 3 cm in width. The radiographic examination did not exhibit relevant changes. Incisional biopsy performed at the margin of the lesion and histopathologic examination showed specific features of carcinoma cuniculatum, such as a locally invasive pushing pattern, crypt filled with keratin, altered nucleus/cytoplasm ratio, and atypical mitoses. Carcinoma cuniculatum is a rare variant of squamous cell carcinoma, invading primarily the subcutaneous, submucosal, or underlying bone tissues. The patient was referred to the local cancer hospital, and after surgery, the diagnosis was spinocellular carcinoma variant cuniculatum, with invasion greater than 4 mm, TNM (tumor–node–metastasis) classification: T4a, N2b, unidentified M; stage IV. The patient is being followed up.
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