Abstract
Dendrobium officinale Kimura et Migo is a commercially and pharmacologically highly prized species widely used in Western Asian countries. In contrast to the extensive genomic and transcriptomic resources generated in this medicinal species, detailed metabolomic data are still missing. Herein, using the widely targeted metabolomics approach, we detect 649 diverse metabolites in leaf and stem samples of D. officinale. The majority of these metabolites were organic acids, amino acids and their derivatives, nucleotides and their derivatives, and flavones. Though both organs contain similar metabolites, the metabolite profiles were quantitatively different. Stems, the organs preferentially exploited for herbal medicine, contained larger concentrations of many more metabolites than leaves. However, leaves contained higher levels of polyphenols and lipids. Overall, this study reports extensive metabolic data from leaves and stems of D. officinale, providing useful information that supports ongoing genomic research and discovery of bioactive compounds.
Highlights
The genus Dendrobium is one of the largest genera of the Orchidaceae comprising 1500–2000 species widely distributed in Asia and Northern Australia [1]
Biotechnology Co., Ltd. (Wuhan, China) and the widely targeted metabolomics strategy offer a platform to detect a great diversity of metabolites in D. officinale as previously reported in tomatoes [22], Prunus mira [23], and hulless barley [24,25,26]
649 metabolites were successfully detected in both sample types (Table S1), which was approximately five times the number of metabolites detected in the previous study [20]
Summary
The genus Dendrobium is one of the largest genera of the Orchidaceae comprising 1500–2000 species widely distributed in Asia and Northern Australia [1]. Among these species, Dendrobium officinale Kimura et Migo is a commercially and pharmacologically valuable species. The special pharmacological actions on gastritis, diabetes, cancer, fatigue, and ageing ranked D. officinale as “the first of the Chinese nine fairy herbs” [3,4,5]. The major bioactive compounds reported in D. officinale include alkaloids, polyphenols, and polysaccharides [2,6,7,8,9,10]. The key alkaloid, sesquiterpene dendrobine, has been reported as anti-hypertensive, anti-cancer, analgesic, and antipyretic [11,12]
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