Abstract
Adverse oral mucosa reactions resulting from imatinib and/or allopurinol use is very uncommon. Herein we report a new case of a 70-year-old female patient who was under imatinib and allopurinol treatment for 6 months against chronic myeloid leukemia, which developed extensive lichenoid eruptions in the oral mucosa, in addition to multiple cutaneous reactions in the skin, foot with the presence of pruritic violaceous nodules and diffuse whitish plaques. Microscopic exam of the cutaneous biopsy revealed hyperkeratosis, acanthosis and an intense chronic inflammatory infiltration in the underlying connective tissue that disrupted epithelial basal cell layer. The medical history together with clinic and microscopic features led to a final diagnosis of lichenoid reaction because of imatinib and/or allopurinol use. Allopurinol was interrupted and imatinib changed for dasatinib. Systemic and local corticosteroid therapy started and after forty-five days of follow-up, the lesions completely disappeared.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
