Abstract
Extensive Basal Cell Adenocarcinoma Involving Minor Salivary Gland of the Hard Palate: A Rare Entity
Highlights
Basal cell adenocarcinoma (BCAC) accounts for 1.6% of all salivary gland neoplasms and 2.9% of all malignant salivary gland neoplasms with the majority of the cases occurring in the parotid gland (Gnepp et al, 2009)
The majority of BCAC develops de novo but 23% of cases may arise from a pre-existing basal cell adenoma (BCA) (Muller and Barnes, 1996)
The neoplastic cells were positive for pan cytokeratin (CKAE1/AE3), cytokeratin 7 (CK7) (Fig. 3a), P63, cytokeratin 5/6 (CK5/6) and vimentin with focal positivity for P53 (Fig. 3b), epithelial membrane antigen (EMA), S100 and P40
Summary
Basal cell adenocarcinoma (BCAC) accounts for 1.6% of all salivary gland neoplasms and 2.9% of all malignant salivary gland neoplasms with the majority of the cases occurring in the parotid gland (Gnepp et al, 2009). A 56-year-old Malay male, an active smoker, presented with five years history of a painless hard palate mass which was gradually increasing in size. It was associated with anosmia, unprovoked epistasis, dysphagia and intermittent difficulty in breathing for the past one year. The neoplastic cells were positive for pan cytokeratin (CKAE1/AE3), cytokeratin 7 (CK7) (Fig. 3a), P63, cytokeratin 5/6 (CK5/6) and vimentin with focal positivity for P53 (Fig. 3b), epithelial membrane antigen (EMA), S100 and P40. They were negative for CD117 (Fig. 3c), smooth muscle actin (SMA), carcinoembryonic antigen (CEA), CK20 and CD10 stains. The mass extends anterosuperiorly to abut the frontal sinus and involve the right maxillary sinus, anterior ethmoid air cells, right posterior ethmoid air cells, sphenoid sinus and bilateral nasal cavities
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