Abstract
A simple and practical procedure has been adopted for one pot synthesis of benzimidazole derivatives under mild reaction conditions, starting from cinnamyl alcohol (COH) with bimetallic nanoparticles (BNPs) and supported bimetallic nanoparticles of Cu, Ti, Zn, Mn, Ag, and Co. All the catalysts were characterized by Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDX), X-Ray Diffractometry (XRD), Brunauer Emmett-Teller (BET) surface area, and pore size analyzer. The products were identified/quantified with 1HNMR, FT-IR, and MS. 98% yield of substituted derivatives of benzimidazole was obtained with Cu–Ti supported on FMWCNTs in ethanol with excellent selectivity. Quantum chemical calculations of molecular reactivity of substituted cinnamaldehyde (CHO) and ortho phenylenediamine (OPD) have good consistency with experimental results. The returns of this work were the use of readily available catalysts, high yield, short reaction time, and simplicity of the process.
Highlights
In heterocyclic aromatic organic compounds, benzimidazole is an important moiety which is made up of the fusion of benzene and imidazole rings [1]
We are going to use available, less toxic, reusable, and low-cost catalysts combined with a simple procedure, to provide an economic and waste-free chemical method for the synthesis of benzimidazole derivatives and simple descriptor will be developed for investigating the effect of substitution on the molecular reactivity of CHO and ortho phenylenediamine (OPD)
Cinnamyl alcohol selectively oxidized to cinnamaldehyde over bimetallic nanoparticles (BNPs) and
Summary
In heterocyclic aromatic organic compounds, benzimidazole is an important moiety which is made up of the fusion of benzene and imidazole rings [1]. For the synthesis of substituted derivatives of benzimidazole, heterogeneous and homogeneous catalysis have gained extensive attraction due to the advantageous approach of these techniques which include easy availability, simple handling, and easy workup [22] Most of these methods have some limitations, for example laborious workup procedure, long reaction times, high temperature, use of expensive catalyst, by-product formation, low yields, and elevated reaction conditions [23,24,25,26,27]. We are going to use available, less toxic, reusable, and low-cost catalysts combined with a simple procedure, to provide an economic and waste-free chemical method for the synthesis of benzimidazole derivatives and simple descriptor will be developed for investigating the effect of substitution on the molecular reactivity of CHO and OPD using density functional theory with B3LYP/6-311++ G (d, p)
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