Abstract
The extended physical and chemical stability of 5-fluorouracil and methotrexate in 0.9% sodium chloride injection in PVC containers was monitored for periods of up to 3 months and compared to solutions stored in glass containers. For 5-fluorouracil, 50 mg/ml solutions stored at room temperature are stable for up to 42 days and 5 mg/ml solutions for up to 13 weeks of refrigerated storage (5 ± 3°C) plus an additional week at room temperature. Methotrexate solutions at concentrations ranging from 1.25 to 12.5 mg/ml are stable for up to 15 weeks of refrigerated storage followed by an additional week at room temperature. No physical or chemical modifications of the solutions were observed, the only limiting factor for long-term stability being a progressive increase in drug concentration due to evaporative water loss from the PVC containers. Except for this slight increase in drug concentration, the same results were obtained for both plastic and glass containers.
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