Extended spectrum β lactamase producing Escherichia coli in urinary tract infections tip-off to evaluate treatment practice

Abstract

Urinary tract infection (UTI) is one of the commonest infections worldwide. Although, the spectrum of etiological agents causing UTI have not changed but the antimicrobial susceptibility profile among them is changing over time and area specifically along with increase in antimicrobial resistance. Hence, this study was done to analyse the etiological agents and susceptibility pattern of E. coli, the most common UTI pathogen. Antibiotic susceptibility pattern and bacteria isolated from urine of patients who visited hospital between January 1 to December 31, 2015 was done. Bacteria were identified by standard microbiological methods and susceptibility test was done according to Kirby Bauer disc diffusion method. Of 107 urine samples, E. coli 73 (67.7%) was the most common isolate followed by Staphylococcus and Klebsiella spp. Most of E. coli isolates were sensitive to amikacin and nitrofurantoin. Out of total E. coli isolates, 57 were ESBL producers and 28 were MBL producers. The result indicates increase in multidrug resistant strains of E. coli. Further, study indicates the need for periodic monitoring of drug susceptibility pattern in a way to prevent the spread, and development of antimicrobial resistant strains, eventually. Keywords: E. coli, urinary tract infection, antibiotic resistance