Extended Release Matrix Tablets of Nateglinide: Formulation and In vitro Evaluation

Abstract

In the present study to establish oral extended release tablets of Nateglinide using different polymers. The tablets were prepared using Xanthan gum, HPMC K15, Carbapol 934 using different polymers to impart extended release study. Tablets were evaluated by different parameters such as weight variation, content uniformity, thickness, hardness, IR spectral analysis, in vitro release studies and kinetic analysis of dissolution data. The present study concluded that extended release tablets of Nateglinde can be a good way to increases the dissolution and bioavailability of Nateglinde.