Abstract
Introduction: The mitochondrial viability of islet beta cells is critical for two key functions: first, the provision of energy for maintenance of cellular metabolism and homeostasis, and second, the induction of glucose stimulated insulin secretion. Recently the measurement of the oxygen consumption rate (OCR) in combination with the isolation factor, a marker of islet size, has been proposed as a new quality control parameter of islets destined for transplantation for the therapy of type 1 diabetes.
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