Abstract
To describe quantitative cytophotometric expression of the marker caspase-3 in colloid goiter and in papillary carcinoma of the thyroid, comparing the immunoexpression between them. An immunohistochemistry study has been made on the protein caspase-3 in 17 of paraffin blocks of papillary carcinoma of the thyroid and 20 cases of colloid goiter, using SAMBA 4000 ® (System of Microscopic Analysis of Automatic Search), aiming analysis of the two variables: marker index and optical density. Statistic analysis indicated a significant difference for marker index between colloid goiter and papillary carcinoma, being this difference larger in the carcinoma. Significant difference in optical density hasn't been found. For colloid goiter, the estimated correlation coefficient between the marker index and optical density was 0,72, indicating the rejection of the null hypothesis (p <0,001), affirming that positive and significant association exists between them. For the papillary carcinoma of the thyroid, the same correlation was 0,34 and so, it is not possible to affirm that there's an association between them. For colloid goiter there is a positive and significant association between the two variables - marker index and optical density -, while for the papillary carcinoma, this is not proved. The quantitative analysis for caspase-3 demonstrates that apoptosis is larger in the papillary carcinoma of the thyroid than in colloid goiter.
Highlights
Colloid goiter is an increase in volume of the thyroid gland caused by hyperplasia of the parenchyma, leading to a state of excessive follicular proliferation
This paper aims to describe the quantitative cytophotometric expression of caspase-3 in colloid goiter and papillary carcinoma of the thyroid and compare the results of caspase-3 immunoexpression between them
The frequency of normality presented by the labeling index in colloid goiter predominated in the ranges from 25.1 to 50 (25%) and 50.1 to 75 (30%)
Summary
Colloid (or nodular) goiter is an increase in volume of the thyroid gland caused by hyperplasia of the parenchyma, leading to a state of excessive follicular proliferation. The classification of goiter is described as diffuse and nodular, and it is uni or multinodular. The classification can be in endemic or sporadic, given the endemic goiter that affects more than 10% of the population of a specific geographical area and sporadic goiter being caused by a range of factors – environmental, immunological and genetic – that interfere with hormone synthesis. Thyroid cancer is the most common malignancy of the endocrine system, predominating in females between 25 to 65 years old. Exposure to radiation in head and neck, personal history of goiter, thyroid nodule and family background of thyroid cancer are important[1]
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