Expressions of VEGF and mutant p53 gene and their clinical significance in lung cancer

Abstract

To explore the relationship between VEGF and mutant p53 ( mtp53) expression and its relation to the physiopathological characteristics of lung neoplasms. The expression of VEGF and mtp53 was detected in 120 lung cancer lesions, paracancerous lesions and 40 benign pulmonary lesions by immunohistochemical staining ( LSAB methods) . VEGF and mtp53 gene expressions in lung cancer tissues were significantly higher than those in paracancerous and benign pulmonary tissues ( P < 0. 01) . VEGF and mtp53 expression was closely related to the size of primary cancer, lymph node status, P-TNM stages, cell differentiation grade of lung cancer ( P < 0. 01) . A highly positive relation was found between VEGF and mtp53( P < 0. 01) . The results suggest that expression of VEGF and mtp53 gene may plays an important role in the oncogenesis and development of lung cancer and may be served as a tumor marker to evaluate the biological behavior of lung cancer.