Abstract
ObjectiveWe aimed to investigate the relationship of expression of matrix metalloproteinase-7 (MMP-7), tissue inhibitor of metalloproteinase-1 (TIMP-1) and cyclooxygenase-2 (COX-2) in colon cancer and its predecessor colon polyp.Materials and methodsThis study included 29 patients with colon polyp, 19 patients with colon cancer and 65 healthy control subjects. The expressions of MMP-7, TIMP-1 and COX-2 were investigated by real time-polymerase chain reaction (RT-PCR).ResultsThe expressions of TIMP-1, COX-2 and MMP-7 levels were significantly higher in polyp tissue compared to normal tissue (p = 0.024, p < 0.001, p = 0.009, respectively). Expression of TIMP-1, COX-2 and MMP-7 in cancer tissues were higher than both normal tissue and polyp tissue (p = 0.009 and p = 0.001; p < 0.001 and p < 0.001; p = 0.029 and p = 0.008, respectively). In the cancer group, no significant relationship was detected between metastasis and MMP-7, TIMP-1 and COX-2 expressions (p > 0.05). In the polyp tissues, no significant relationship was detected between the histologic type and size of polyps and MMP-7, TIMP-1 and COX-2 levels (p > 0.05). The areas under the receiver operating characteristic (ROC) curve for the cancer group were 0.821 for TIMP-1, 0.888 for COX-2, and 0.880 for MMP-7 (p = 0 < 0.001).ConclusionA role and implication of expressions of MMP-7, COX-2 and TIMP-1 in colon cancer is predicted.How to cite this articleBengi G, Keles D, Topalak Ö, Yalçin M, Kiyak R, Oktay G. Expressions of TIMP-1, COX-2 and MMP-7 in Colon Polyp and Colon Cancer. Euroasian J Hepato-Gastroenterol 2015;5(2):74-79.
Highlights
Colorectal cancer (CRC) is one of the most common malignancies in developed countries
Colorectal cancer development is a multi-step process that occurs as a result of mutations in oncogenes, such as K-ras, adenomatous polyposis coli (APC) gene and tumor suppressor p53 gene that lead to cellular degeneration and uncontrolled cell proliferation
The mean tissue inhibitor of metalloproteinase-1 (TIMP-1), COX-2 and matrix metalloproteinase-7 (MMP-7) levels were significantly higher in polyp tissue compared to normal tissue (p = 0.024, p < 0.001, p = 0.009, respectively)
Summary
Colorectal cancer (CRC) is one of the most common malignancies in developed countries. The vast majority of CRC (98%) are adenocarcinomas, which almost always grow from adenomatous polyps. Colorectal cancer development is a multi-step process that occurs as a result of mutations in oncogenes, such as K-ras, adenomatous polyposis coli (APC) gene and tumor suppressor p53 gene that lead to cellular degeneration and uncontrolled cell proliferation. The fecal occult blood test (FOBT) is a noninvasive and simple test, less than 10% of positive results are truly CRC positive. When all these tests are considered, serum biomarkers are still not diagnostic for CRC
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