Abstract
Objective To investigate the effects of sleep deprivation on expressions of Mir-132, mir-134 in the different regions of rat brain. Methods All the male SD rats were divided into control group (normal sleep group), sleep deprivation (SD). The modified multiple platform method (MMPM) was used to establish sleep deprivation model. Mir-132, mir-134 level was detected by real time PCR. Results Mir-132 were significantly increased in SD groups in hippocampus compared with the control groups(51.87±8.13 vs 67.25±7.59)(P 0.05). Cortex mir-132 level in SD group and control group was 1.57±0.10, 1.48±0.11 respectively, and it was 1.37±0.09, 1.36±0.11 in thalamus; Cortex mir-134 level in SD group and control group was 98.26±5.17, 100.80±4.15 respectively, and it was 97.56±6.28, 91.01±4.07 in thalamus. Conclusion The upregulation of mir-132 and downregulation of mir-134 implies that two miRNAs did opposite actions in the processes of sleep deprivation. This findings indicate that hippocampus mir-132, mir-134 levels in the SD rat may reflect associated depressive pathophysiological processes. Key words: Sleep deprivation; MicroRNA-132; MicroRNA-134
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