Abstract
Objective To detect the expressions of interleukin-11 (IL-11) and interleukin-11 receptor α (IL-11Rα) in non-small cell lung cancer (NSCLC) cell lines, and explore their clinical significances. Methods The expressions of IL-11 and IL-11Rα in NSCLC cell lines A549, H2228, healthy lung small airway epithelial cell (SAEC) line cytoplasm, cell membrane and nucleus were detected by Western blot. Results The expressions of IL-11 and IL-11Rα were low in the cell membrance and nucleus (cell membrane: IL-11 0.04±0.03, IL-11Rα 0.05±0.03; nuclear: IL-11 0.45±0.19, IL-11Rα 0.07±0.02; P < 0.01); The expressions of IL-11 and IL-11Rα in A549 and H2228 cell lines were significantly increased compared with those of SAEC cell lines in the cell membrance and cytoplasm (P < 0.01); Among the A549 cell lines, the expressions of IL-11 and IL-11Rα in cell nucleus were much higher than those of the cell membrance and cytoplasm (P < 0.01). Among the H2228 cell lines, the expression of IL-11 in cytoplasm was the highest and the expression of IL-11Rα was the highest in the cell nucleus (P < 0.01). Conclusion The expressions of IL-11 and IL-11Rα are high in NSCLC cell lines, and it is good for the screening and early diagnosis of lung cancer by detecting the expressions of IL-11 and IL-11Rα. Key words: Carcinoma, non-small-cell lung; Interleukin-11; Interleukin-11 receptor alpha subunit; Diagnosis
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