Abstract
Objective To elucidate the expressions of E-cadherin, VEGF, and Cath-D in laryngeal squamous cell carcinoma and cervical , lymph node met astatic. Methods Specimens of 60 laryngealsquamous carcinomas were used to study by immunohistochemical staining to probe the expression of E-cadherin, VEGF and Cath-D. Results Positive expressions of E-cadherin, VEGF and Cath-D were found in 75% , 83% and 66% of laryngeal squamous carcinoma specimens respectively. There were a positive relationship between Cath-D, E-cadherin and VEGF expression. The E-cadherin, VEGF and Cath-D in patients with cervical lymph node metastases was significantly higher than those without metastasis. No correlation was identified between E-cadherin and Cath-D staining. E-cadherin in VEGF-positive and Cath-D-positive tumors was significantly higher that VEGF and Cath D negative tumors. These phenomena were more easily found in patient with cervical lymph node metastasis than patients without metastasis. Conclusion E-cadherin, VEGF and Cath-D expression are important monitor markers in laryngeal squamous cell carcinoma with cervical lymph node metastasis. There might be interaction among Cath-D, E-cadherin and E-cadherin. Key words: Cadherins/ME; Cathepsin D/ME; Vascular endothelial growth factors/ME; Llaryngeal neoplasms /ME/PA; Lymphatic metastasis
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