Abstract
Objective To detect the expressions of AKT, endothelial nitric oxide synthase (eNOS), and vascular endothelial growth factor-c (VEGF-C) in malignant melanoma (MM) in children and to study their roles in lymphatic metastasis. Methods The expressions of AKT, eNOS, and VEGF-C were detected by immuno- histochemistry in 20 cases of malignant melanoma in children and 8 normal. Results The positive expressions of AKT, eNOS, and VEGF-C in malignant melanoma in children (the positive expression rates were 66.59%, 63.41%, and 73.28%) were significantly higher than those in normal tissue. The expressions of AKT, eNOS, and VEGF-C in malignant melanoma of lymphatic metastasis was higher than those without lymphatic metastasis(P values were less than 0.05, 0.01, and 0.01). The expression of AKT showed a significant positive correlation with VEGF-C(r=0.528, P<0.01), and the expression of VEGF-C showed a positive correlation with eNOS (r=0.470,P<0.05). Conclusion The expressions of AKT, eNOS, and VEGF-C may associate with the lymphatic metastasis of malignant melanoma in children. Key words: Malignant melanoma in children; AKT; VEGF-C; eNOS; Lymphatic metastasis
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