Expressions and their Significance of Ki-67, p53, and survivin in esophageal cancer and precancerosis

Abstract

Objective To investigate the expressions and clinical significance of Ki-67, p53, and survivin in esophageal cancer and precancerosis. Methods The expressions of Ki-67, p53, and survivin proteins were detected by immunohistochemical staining in 40 normal esophageal mucosa, 136 precancerosis (42 mild atypical hyperplasia, 43 moderate atypical hyperplasia, and 51 severe atypical hyperplasia), and 68 esophageal cancer tissues. The correlation of three proteins expressed in esophageal carcinoma tissues was analyzed. Results The positive expression rate of Ki-67 was 0 (0/40)for normal epithelium, 35.7% (15/42) for mild dysplasia, 51.2% (22/43) for moderate dysplasia, 74.5% (38/51) for severe dysplasia, 92.6% (63/68) for squamous carcinoma, respectively. The positive expression rate of p53 protein was 0 (0/40) for normal epithelium, 28.6% (12/42) for mild dysplasia, 46.5% (20/43) for moderate dysplasia, 52.9% (27/51) for severe dysplasia, 67.6% (46/68) for squamous carcinoma, respectively. The positive expression rate of survivin protein was 0 (0/40) for normal epithelium, 38.1% (16/42) for mild dysplasia, 55.8% (24/43) for moderate dysplasia, 64.7% (33/51) for severe dysplasia, 89.7% (61/68) for squamous carcinoma, respectively. Rank correlation analysis showed that abnormal expressions of Ki-67, p53, and survivin were correlated significantly with the pathological grading of the lesions (r=0.637, 0.454, 0.590, P<0.01). The expressions of Ki-67, p53, and survivin were positively correlated in esophageal carcinoma (r=0.407, 0.646, P<0.01). Conclusions The abnormal expressions of Ki-67, p53, and survivin were associated with the processes of the esophageal canceration, and the joint detection with three parameters has important clinical value. Key words: Esophageal neoplasms/ME; Esophageal diseases/ME; Ki-67 antigen/ME; Genes, p53; Microtubule-associated proteins/ME