Abstract
Objective To investigate the expressions and significance of matrix metalloproteinase （ MMP-2 ,MMP-9 ）and tissue inhibitor of matrix metalloproteinase（ TIMP-2 ,TIMP-1 ）in cervical cancer. Methods Ninety-eight patients with early invasive cervical cancer（ ICC）and 68 patients with cervical intraepithelial neoplasm（ CIN）,confirmed by pathology,were selected,and 36 cases of normal cervical epithelium（NCE）were selected as control. The expression of MMP-2,MMP-9,TIMP-2 and TIMP-1 in all samples were examined by reverse transcription PCR. Expression rate and expression level of ev-ery factor were recorded. The results were compared among the groups. Results Compared with control group,the expression rate and expression levels of MMP-2,MMP-9 in ICC group and CIN group were significantly higher,TIMP-2 and TIMP-1 in ICC group and CIN group were significantly lower（ P ﹤0. 05）. Expression rate and expression levels of MMP-2,MMP-9 in CIN group were significantly lower than those in ICC group,TIMP-2 ,TIMP-1 in CIN group were significantly higher than those in ICC group（ P﹤0. 05 ）. The expression levels of MMP-2 ,MMP-9 in the tumor edge of the ICC group were significantly higher than those in the tumor center,while the expression levels of TIMP-2 ,TIMP-1 were significantly lower than those in the tumor center（ P ﹤0. 05 ）. Conclusions MMP-2 ,MMP-9 and TIMP-2 ,TIMP-1 may play an important role in the development,progression,invasion and metastasis of cervical cancer. Key words: Matrix metalloproteinase; Tissu inhibitor of matrix metalloproteinase; Cervical cancer
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