Expressions and clinical significances of microRNA-126 and vascular endothelial growth factor in gastric carcinoma

Abstract

Objective To observe the expressions of microRNA-126 (miR-126) and vascular endothelial growth factor (VEGF) in gastric carcinoma tissues, and their associations with clinicopathologic features in gastric carcinoma. Methods Fifty cases of gastric carcinoma and matched tumor adjacent tissue specimens were collected from January 2012 to March 2014 in Shangqiu First People′s Hospital of He′nan Province. Expression levels of miR-126 and VEGF were examined using reverse transcriptase-polymerase chain reaction. Their correlations and the relationships between them and the clinicopathologic features in gastric carcinoma were analyzed. Results The expression levels of miR-126 in the tumor tissues and in the adjacent tissues were 0.652±0.102 and 0.379±0.069, and the expression levels of VEGF in the two kinds of tissues were 1.523±0.142 and 0.604±0.152, with statistical differences (t=8.374, P=0.001; t=29.508, P=0.000). The expressions of miR-126 and VEGF were significantly positively correlated (r=0.735, P=0.001). The expre-ssions of miR-126 and VEGF were associated with TNM stage (t=22.981, P=0.001; t=18.053, P=0.001), depth of tumor invasion (t=26.792, P=0.001; t=20.234, P=0.001) and tumor node metastasis (t=26.668, P=0.001; t=14.857, P=0.001). Conclusion miR-126 is high expressed in the gastric carcinoma tissue, which may up-regulate the expression of VEGF, and lead to the formation of new blood vessels, then to promote gastric carcinogenesis and the development process. Key words: Stomach neoplasms; MicroRNAs; Vascular endothelial growth factors