Expressions and clinical significances of CLDN1 and CLDN4 in human hepatocellular carcinoma

Abstract

Objective To investigate the expression and clinical significances of CLDN1 and CLDN4 in human hepatocellular carcinoma.Methods Immunohistochemical method was used to detect the expression of CLDN1 and CLDN4 in both hepatocellular carcinoma tissues(60 cases) and normal liver tissues (50 cases)and the relation between CLDN1 and CLDN4 was evaluated.Results The positive rates of CLDN1 and CLDN4 expressions in HCC tissues were 70％ (42/60) and 25％ (15/60) respectively.The positive rates of CLDN1 and CLDN4 expressions in normal liver were 0 (0/50) and 100％ (50/50).The expressions of CLDN1 and CLDN4 had no relationship with age,sex,AFP and degree of tumor differentiation of the patients with HCC.The expression of CLDN4 was correlated with the expression of CLDN1 in HCC.Conclusions The expressions of CLDN1 and CLDN4 in HCC are both abnormal.The expressions ofCLDN4 in HCC are down-regulated and the expressions of CLDN1 in HCC are over-expressed.Abnormal expressions of CLDN1 and CLDN4 in HCC may promote the development and progression of HCC. Key words: CLDN 1 ; CLDN4 ; Human hepatocellular carcinoma ; Immunohistochemistry