Abstract
Objective To study the expressions of matrix metalloproteinase-13 (MMP-13) and p73 in gastric adenocarcinoma, and to explore the associations of the expressions of MMP-13 and p73 with the clinicopathological features, and to evaluate their clinical significances for the prognosis of gastric adenocarcinoma metastasis. Methods The immunohistochemistry SP methods was used to evaluate the expressions of MMP-13 and p73 in 143 cases of gastric adenocarcinoma and 55 normal tissues adjacent to carcinoma, and their associations to the clinicopathologic features were analyzed. Results The expression of MMP-13 in gastric adenocarcinoma was significantly higher than that in adjacent tissues of cancer (67.13% vs 16.35%), with a significant difference (χ2=41.10, P=0.000). The expression of p73 in gastric adenocarcinoma was significantly higher than that in adjacent tissues of cancer (58.74% vs 12.73%), with a significant difference (χ2=33.86, P=0.000). In the gastric adenocarcinoma, the expression of MMP-13 was associated with peripheral lymph node metastasis (χ2=11.835, P=0.001), depth of invasion (χ2=5.177, P=0.032) and TNM stage (χ2=11.107, P=0.001), but it was not correlated with the ages of patients (χ2=0.113, P=0.853), tumor size (χ2=0.338, P=0.591) and tumor differentiation level (χ2=3.628, P=0.072). In the gastric adenocarcinoma, the expression of p73 was associated with peripheral lymph node metastasis (χ2=11.440, P=0.001), tumor differentiation level (χ2=5.407, P=0.025) and TNM stage (χ2=9.497, P=0.003), but it was not correlated with the ages of patients (χ2=1.567, P=0.222), tumor size (χ2=0.841, P=0.392) and depth of invasion (χ2=0.554, P=0.498). The expression of MMP-13 was positively correlated with the expression of p73 in gastric adenocarcinoma group (r=0.684, P=0.000). Conclusion Both MMP-13 and p73 may participate in the development of gastric adenocarcinoma, which can be used as an important index for the evaluation of invasiveness and metastasis in gastric adenocarcinoma. Key words: Stomach neoplasms; Adenocarcinoma; Immunohistochemistry; Matrix metalloproteinase 13; p73
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
