Abstract
Background Human immunodeficiency virus (HIV) is infecting over 34.0 million people worldwide, being responsible for one of the major current pandemics [1]. The most severely affected region is the Sub-Saharan Africa where nearly 1 in 20 adults is infected with HIV, accounting for 69% of infections worldwide [1]. Several strategies to halt HIV spread are currently being pursued, including the use of ectopic microbiocides. This approach is particularly important for women, among which the infection rate can be almost three more times than men. CyanovirinN (CVN) is a lectin-like protein isolated from blue algae Nostoc ellipsosporum. CVN is highly thermo stable and is capable of binding to HIV GP120 protein blocking viral infection [2,3]. In this report we describe the use of transgenic soybean plants as a potential platform to achieve large scale, cost-effective production of CVN.
Highlights
Human immunodeficiency virus (HIV) is infecting over 34.0 million people worldwide, being responsible for one of the major current pandemics [1]
R1 seeds were analyzed by PCR and ELISA-gp[120] followed by nanoUPLC-MSE [5] to characterize and quantify the expression levels of recombinant CVN
Total soluble proteins (TSP) were separated using gel filtration sephadex s200 followed by HPLC C4 reversed phase
Summary
Human immunodeficiency virus (HIV) is infecting over 34.0 million people worldwide, being responsible for one of the major current pandemics [1]. The most severely affected region is the Sub-Saharan Africa where nearly 1 in 20 adults is infected with HIV, accounting for 69% of infections worldwide [1]. Several strategies to halt HIV spread are currently being pursued, including the use of ectopic microbiocides. This approach is important for women, among which the infection rate can be almost three more times than men. CyanovirinN (CVN) is a lectin-like protein isolated from blue algae Nostoc ellipsosporum. CVN is highly thermo stable and is capable of binding to HIV GP120 protein blocking viral infection [2,3]. In this report we describe the use of transgenic soybean plants as a potential platform to achieve large scale, cost-effective production of CVN
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
