Abstract
Cyclical changes of endometrium during menstruation necessitate well-controlled, dynamic movement of fluids across cell membranes. Regeneration of endometrium following menses requires well-balanced angiogenesis. Disturbance of these procedures may lead to AUB. AQPs play a crucial role in transcellular fluid transport and involved in impaired angiogenesis in tumors, suggesting a possible role of AQPs in endometrium. Since the general expression pattern of AQPs in endometrium is still obscure nowadays, we sought to investigate the expression of AQPs completely in normal cyclic endometrium and in patients suffering from AUB.
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