Abstract
PurposeThe aim of this study was to identify differentially expressed microRNAs (miRNAs) that might play an important role in the etiology of retinal degeneration in a genetic mouse model of retinitis pigmentosa (rd10 mice) at initial stages of the disease.MethodsmiRNAs–mRNA interaction networks were generated for analysis of biological pathways involved in retinal degeneration.ResultsOf more than 1900 miRNAs analyzed, we selected 19 miRNAs on the basis of (1) a significant differential expression in rd10 retinas compared with control samples and (2) an inverse expression relationship with predicted mRNA targets involved in biological pathways relevant to retinal biology and/or degeneration. Seven of the selected miRNAs have been associated with retinal dystrophies, whereas, to our knowledge, nine have not been previously linked to any disease.ConclusionsThis study contributes to our understanding of the etiology and progression of retinal degeneration.
Highlights
The aim of this study was to identify differentially expressed microRNAs that might play an important role in the etiology of retinal degeneration in a genetic mouse model of retinitis pigmentosa at initial stages of the disease
Retinitis pigmentosa (RP) is a heterogeneous collection of inherited retinal degeneration diseases that leads to vision impairment and for which there is no standard treatment
In addition to many molecular pathways involved in both survival and death of photoreceptors and RPE cells, there is growing evidence of the role of epigenetic mechanisms as key players in gene expression regulation, retinal development and function, and photoreceptors survival.[1,2]
Summary
The aim of this study was to identify differentially expressed microRNAs that might play an important role in the etiology of retinal degeneration in a genetic mouse model of retinitis pigmentosa at initial stages of the disease
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