Expression profiles of long noncoding RNAs in cardiac stem cells under hyperglycemic conditions

Abstract

From previous reports, the incidence of ischaemic heart disease and acute myocardial infarction is greater in people with diabetes than in nondiabetic individuals, and has suffered from a higher incidence of mortality [ 1 Ahmed B. Davis H.T. Laskey W.K. In-hospital mortality among patients with type 2 diabetes mellitus and acute myocardial infarction: results from the national inpatient sample, 2000–2010. J. Am. Heart Assoc. 2014; 3 Crossref Scopus (36) Google Scholar , 2 Koek H.L. Soedamah-Muthu S.S. Kardaun J.W. Gevers E. de Bruin A. Reitsma J.B. et al. Short- and long-term mortality after acute myocardial infarction: comparison of patients with and without diabetes mellitus. Eur. J. Epidemiol. 2007; 22: 883-888 Crossref PubMed Scopus (46) Google Scholar , 3 Rousan T.A. Pappy R.M. Chen A.Y. Roe M.T. Saucedo J.F. Impact of diabetes mellitus on clinical characteristics, management, and in-hospital outcomes in patients with acute myocardial infarction (from the NCDR). Am. J. Cardiol. 2014; 114: 1136-1144 Abstract Full Text Full Text PDF PubMed Scopus (35) Google Scholar ]. Meanwhile, the risk of post-myocardial infarction death is also increased in diabetic patients compared to those without diabetes. Of 157,142 people with an MI in England and Wales between 2003–2006, the relative risk of death or recurrence of MI for those with diabetes in the first 90 days was 1.3 (95%CI: 1.26–1.33) crude rates and 1.16 (95%CI: 1.1–1.2) when controlling for age, gender, heart failure and surgery for MI compared with those without diabetes [ [4] Brophy S. Cooksey R. Gravenor M.B. Weston C. Macey S.M. John G. et al. Population based absolute and relative survival to 1 year of people with diabetes following a myocardial infarction: a cohort study using hospital admissions data. BMC Public Health. 2010; 10: 338 Crossref PubMed Scopus (15) Google Scholar ]. However, the mechanisms associated with diabetes-induced low myocardial regeneration and repair capability after myocardial injury remain elusive.