Abstract
Expression Profiles and Clinicopathologic Features in Early Resected Non-small-cell Lung Cancer
Highlights
Lung cancer is the leading cause of cancer-related death worldwide and surgical resection is the treatment of choice for early-stage nonsmall-cell lung cancer (NSCLC)
What lessons can be learned from this lung cancer prognostic index (LCPI)? NSCLC has become recognized as being a heterogeneous set of diseases (Reck et al, 2013) and, in patients with lung adenocarcinomas, epidermal growth factor receptor (EGFR) mutations are associated with response to EGFR inhibitors
Paper from Chen and Chen, adjuvant chemotherapy has a nefarious effect on patients with low/intermediate risk of relapse according to the LCPI (Chen and Chen, 2014)
Summary
Lung cancer is the leading cause of cancer-related death worldwide and surgical resection is the treatment of choice for early-stage nonsmall-cell lung cancer (NSCLC). NSCLC has become recognized as being a heterogeneous set of diseases (Reck et al, 2013) and, in patients with lung adenocarcinomas, epidermal growth factor receptor (EGFR) mutations are associated with response to EGFR inhibitors. Targetable mutations have been identified in squamous cell carcinoma of the lung, such as discoidin domaincontaining receptor 1 (DDR2), FGFR1 and others.
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