Abstract
To investigate the difference in the expression of TLRs in monocytes from patients with/without implants. Blood samples from 21 osteoarthritic patients undergoing joint replacement (11 cases) or arthroscopy (10 cases) were tested. Blood samples were obtained within 24 h before surgery and the third postoperative day to measure cell-associated TLRs by FCM. The results showed that in the absence of clinical infection, implantation of joint prosthesis seems to be associated with a significant decrease in circulating TLR2- and TLR7-positive cells, whereas the decrease in TLR4- and TLR9-positive cells was not statistically significant. A small intervention in the form of knee arthroscopy was without effect. TLRs seem to be affected by the implantation of joint prosthesis, perhaps by migration to and entrapment in peri-implant tissues. Due to their role in innate and adaptive immunity, TLRs may have consequences for the postoperative inflammation and infection.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: European Journal of Orthopaedic Surgery & Traumatology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
