Abstract

Aim We investigated the expression pattern of Notch-1 in normal and hypertrophied plantaris muscle of mice. Main methods We performed immunofluorescence of both Notch-1 and the Notch-1-linking molecules. Key findings Immunofluorescence labeling revealed Notch-1 protein in Pax7-positive satellite cells during days 2–6. We observed clear co-localization between Notch-1 and myogenin (4.9 ± 1.3%) in the hypertrophied muscle at 4 days. Several mononuclei (possibly satellite cells) possessed both Notch-1 and Foxo1 in the plantaris muscle subjected to mechanical overloading (4.1 ± 1.2%). Significance Notch-1 may play an important role in the maintenance of quiescent satellite cells.

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