Abstract
Adipokines serve as a human clinical biomarker and they regulate mammalian metabolic functions. Research on adipokine regulation of metabolic function in avian species is limited. The current study is to investigate the profile of plasma adiponectin and several biochemical variables in broilers, to establish the pattern of development. A total of one hundred and fifty-two 1-day-old Arbor Acres broilers were separated by different gender and homogenously divided into 2 groups (male and female), with 6 replicate pens and at least 12 chickens per pen. The data for body weight, plasma variables, and feed consumption were collected at days 3, 7, 14, 21, 28 and 35 after hatching. Plasma monomer adiponectin, high-molecular weight (HMW) adiponectin and biochemical variables, including triacylglycerol, total cholesterol, glucose, high-density lipoprotein and low-density lipoprotein were quantified. Monomer adiponectin was highly correlated with age in a negative fashion and with HMW adiponectin in a positive fashion in both genders in broilers. Moreover, body weight was highly correlated with monomer adiponectin in a negative fashion and positively correlated with HMW adiponectin in growing chickens. It was concluded that monomer adiponectin and HMW adiponectin have highly correlation with age, body weight and biochemical variables in chickens and further investigation is needed for physiological or nutritional functions.
Highlights
In the late 20th century, many adipokines and their physiological functions were discovered (Lago et al, 2007)
Our hypothesis is that chicken adiponectin or high-molecular weight (HMW) adiponectin have a correlation with biochemical variables and physiological manifestations, such as body weight and ages
We hypothesized that chicken monomer adiponectin or HMW adiponectin have a correlation with biochemical variables and physiological manifestations, such as body weight and ages
Summary
In the late 20th century, many adipokines and their physiological functions were discovered (Lago et al, 2007). Exogenous administration of adiponectin to mammals decreases blood biochemical variables, such as glucose, free fatty acids and triglycerides; increases muscular fatty acid oxidation and induces weight loss (Fruebis et al, 2001). Reduced adiponectin levels and actions are associated with obesity and type 2 diabetes. Increasing adiponectin signaling and actions reduces diet-induced obesity, inflammation, insulin resistance, cardiovascular diseases, and type 2 diabetes (Turer & Scherer, 2012; Li et al, 2012). This suggests a promising approach for the treatment of metabolic dysregulation diseases
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