Expression profile of adiponectin and adiponectin receptors in high fat diet feeding chicken

Abstract

Adiponectin is a circulatory cytokine secret from adipose tissue and exerts critical metabolic function in mammals. Avian also expressed adiponectin and adiponectin receptors in peripheral tissues, whereas the expression profiles are very different from mammals and the role of its unique profile is still unknown. The current study explore the role of adiponectin and adiponectin receptors in chicken by high‐fat diet feeding. Twenty Taiwan L2 chickens were challenge with 10% high‐fat diet for 6 weeks. The results are showed that body weight, plasma triglyceride, plasma cholesterol and DPP4 were increased by high‐fat diet treatment. Interestingly, we first demonstrated that chicken macroadiponectin and DsbA‐L (adiponectin multimerization enzyme) were elevated by high‐fat diet feeding. Moreover, the mRNA expression of adiponectin and adiponectin receptors were increased in fat tissues by high‐fat diet treatment. For metabolic‐related genes analysis, FAS, ATGL, LPL and PPAR γ were increased in high‐fat diet group. These results were suggested that high‐fat diet treatment may alter the expression profiles of adiponectin and metabolic genes in chicken fat tissue. In sum, we explore the effect of high‐fat diet in expression profile of adiponectin and its receptors in chicken and provide the new insights for how adipokines modulate physiological function in avian species.Support or Funding InformationThe authors would like to express our gratitude to the laboratory members for their help and input during this study.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.