Abstract
While nucleotide substitutions in both regulatory and coding regions are the two facets of functional divergence after gene duplication, evidence is limited for our understanding the extent to which regulatory changes can occur after gene (genome) duplication. Fortunately, the complete yeast genome sequence and the whole-genome micro-array expression data provide a unique opportunity for resolving this issue. In the yeast genome, a genome-wide duplication may result in 54 homologous chromosome block pairs, including 452 gene pairs. On the other hand, Chu et al. [Science 282 (1998) 699] used DNA micro-arrays containing nearly every yeast gene to assay changes in gene expression during sporulation, which consists of meiosis and spore morphogenesis. Our results have shown that, for a subset of gene pairs that at least one duplicate gene is induced during sporulation, there is a significant association between expression and the presence of DNA binding site MSE, while no such association is observed for the rest of homologous gene pairs.
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