Abstract
• Epithelioid cell granulomas have hypoxic microenvironment acting as a stimulus for angiogenesis . • The significantly increased number of vessels were seen in the granulomatous areas compared to non-granulomatous areas indicating the role of neo-angiogenesis in disease pathogenesis. • VEGF expression was markedly reduced in the mucosal epithelium of granulomatous area suggesting defective VEGF production by the intestinal epithelium making it prone to injury. • Altered vasculature of the granuloma associated vessels might be a potential therapeutic target for intestinal TB in future, in conjunction with anti-tubercular treatment.
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