Abstract
Skin inflammation and epidermal hyperproliferation caused by damage or irritants including tumor promoting agents critically depend on local eicosanoid release (1). Disturbances of the eicosanoid homeostasis are a hallmark of hyperprolifertive skin diseases such as psoriasis and epidermal neoplasia (1–3). The generation of eicosanoids is initiated primarily by liberation of arachidonic acid from the sn-2 position of membrane phospholipids as catalyzed by specific phospholipases A2 (PLA2) (4). One particular PLA2 type with selectivity for the hydrolysis of arachidonic acid was recently identified in the cytosol of mammalian tissues and cells to be a Ca2+-dependent 85 kDa enzyme exhibiting an apparent molecular weight of 100 kDa in SDS/PAGE.KeywordsArachidonic AcidCell FractionBullous PemphigoidPLA2 ActivityGerman Cancer ResearchThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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