Abstract
Objective To evaluate the expression of CD166 in colorectal carcinoma (CRC) tissues in order to explore its significance in CRC pathogenesis. Methods The expression of CD166 mRNA was detected by RT-PCR in CRC tissues and normal colorectal tissues outside the cancers in 23 patients with confirmed CRC. Its association with clinicopathological parameters was analyzed. Results The positive rate (95.7%) and expression level (0.309±0.145) of CD166 mRNA in CRC tissues were statistically higher than those of 39.1% and 0.109±0.255 in the normal colorectal tissues (P<0.01). No significant association of CD166 mRNA expression with age, gender, Dukes stages, tumor locations, tumor sizes or histological types of CRC was found. Conclusion CD166 mRNA expression is up-regulated in CRC tissues, which is not associated with clinicopathological parameters. Key words: Tumor stem cell; Colorectal neoplasm; CD166; Tumor marker; Dukes stage; Adenocarcinona
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