Abstract
The incidence and mortality of intrahepatic cholangiocarcinoma (ICC) are increasing worldwide. High invasion and metastasis are one of the main causes of death in patients. The selection of reasonable and effective molecular markers to evaluate the prognosis of patients with ICC has important clinical guiding significance. In this study, the expression of Tspan protein in ICC and normal tissues was compared, the correlation between Tspan expression and pathological features of patients was analyzed by the logistic regression model using multivariate analysis, and the relationship between Tspan8 expression and prognosis of ICC patients was analyzed by the Kaplan–Meier survival curve. The results showed that Tspan8 is highly positive in ICC tissues, TNM stage, degree of tumor differentiation, lymph node metastasis, and Tspan8 protein expression were independently correlated, and the overexpression of Tspan was associated with the prognosis of ICC invasion and metastasis. This provides a new idea for clinical treatment.
Highlights
Intrahepatic cholangiocarcinoma (ICC) is adenocarcinoma originating from secondary bile ducts and their branched epithelium, accounting for about 10% of primary liver cancers [1]
At present, the prediction of ICC disease stage and prognosis is mainly based on the pathological characteristics of tumors, there is a lack of information at the molecular level, and the research on adjuvant therapy such as targeted drugs cannot provide more information [3]. erefore, it is of great significance to find and identify effective biomarkers, explore their mechanisms in the occurrence and development of ICC, and provide effective molecular targets for the early diagnosis, treatment, and prognosis assessment of ICC
TM4SF/Tspan is a special cell membrane glycoprotein, which widely exists in mammalian body
Summary
Intrahepatic cholangiocarcinoma (ICC) is adenocarcinoma originating from secondary bile ducts and their branched epithelium, accounting for about 10% of primary liver cancers [1]. Tspan plays multiple roles in human body It can participate in the regulation of multiple biological functions such as tumor metastasis, viral infection, platelet aggregation, and immune response and affect a variety of Evidence-Based Complementary and Alternative Medicine biological behaviors including the adhesion, migration, differentiation, and malignant transformation of cells [6]. There are few studies on its role in ICC and the correlation between its clinical changes and the prognosis of ICC patients is not clear [7]. Erefore, the focus of this study is to observe the expression changes of Tspan in patients with intrahepatic cholangiocarcinoma and its relationship with clinicopathological features and prognosis, aiming to provide a corresponding theoretical basis for clinical application research, which is reported as follows There are few studies on its role in ICC and the correlation between its clinical changes and the prognosis of ICC patients is not clear [7]. erefore, the focus of this study is to observe the expression changes of Tspan in patients with intrahepatic cholangiocarcinoma and its relationship with clinicopathological features and prognosis, aiming to provide a corresponding theoretical basis for clinical application research, which is reported as follows
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