Abstract
Toll-like receptor 4 (TLR4) plays an important role in modulating innate immunity. Type 2 diabetes mellitus (T2DM) is a chronic disease that is characterized by impaired insulin resistance and abnormal immune response. Genetic background and consequently genetic factors might have a key role in both onset and progression of T2DM-related complications. The aim of this work was to study the role of toll-like receptor 4 (TLR4) in the development of type 2 diabetes mellitus (T2DM). This study was carried out on 90 subjects, 30 type 2 diabetic patients, 30 patients with impaired glucose tolerance and 30 age and gender matched healthy controls. mRNA expression of (TLR4) was assessed by reverse transcriptase PCR (RT-PCR) using real time PCR.. Results showed significant statistical difference between the three studied groups regarding BMI, serum FBG, HDL, TGs, TC, LDL, HOMA -IR and mRNA expression of TLR4 with highest level of TLR4 mRNA expression in T2DM patients. From this study, it might be concluded that high expression of (TLR4) is associated with T2DM.
Highlights
Diabetes mellitus (DM) is a chronic metabolic disease, and its incidence is growing worldwide
The aim of this work was to study the role of toll-like receptor 4 (TLR4) in the development of type 2 diabetes mellitus (T2DM)
Insulin resistance was assessed by homeostatic model assessment of insulin resistance (HOMAIR) (10).Measurement of TLR4 mRNA expression was performed using reverse transcriptase PCR (RT-PCR) using real time PCR
Summary
Diabetes mellitus (DM) is a chronic metabolic disease, and its incidence is growing worldwide. TLR4 is a single trans membrane non catalytic protein that could be used to identify the molecules with conservative structure from microorganisms (4). TLR4 is a trans membrane protein, member of the toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family. It has been proposed that T2DM may be the consequence of the stimulation of Toll-like receptors (TLRs), a family of pattern-recognition receptors able to detect microbial conserved components and trigger protective host responses, and implicated in mediating chronic inflammatory diseases, including obesity and diabetes (6). The aim of this work was to study the role of toll-like receptor 4 (TLR4) in the development of type 2 diabetes mellitus (T2DM)
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