Abstract
Objective To detect Toll like receptor 2(TLR2) expression in tissues of normal human placenta and fetal membranes.Method Placenta and fetal membranes(5 cases)were collected from women with intact membranes underwent elective cesarean sections at term.Expression and localization of TLR2 was detected by RT-PCR,Westen blot analysis and immol/Lunohistochemistry.Results TLR2 messenger RNA was found in tissues of placenta and fetal membranes.Westen blot analysis with TLR2 antibody also yielded positive results for placenta and fetal membranes with one band site around 50 000.Immol/Lunohistochemical localization of TLR2 showed it to be present at syncytotrophoblast of placenta,cytotrophoblast of chorion and epithelial cell of amnion.Conclusion TLR2 expression in tissues of placenta and fetal membranes suggest that TLR2 may play an important role in the innate immol/Lunity of placenta. Key words: Placenta; Fetal membranes; Trophoblasts; Toll like receptor 2; Pattern recognition receptor; Innate immunity
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