Abstract
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease involving multiple organs. It is currently accepted that several genetic, environmental, and hormonal factors are contributing to its development. Innate immunity may have a great influence in autoimmunity through Toll-like receptors. TLR-7 recognizing single-strand RNA has been involved in SLE. Its activation induces intracellular signal with attraction of MyD88 and NF-kBp65, leading to IFN-α synthesis which correlate with disease activity. To assess the expression of TLR-7, MyD88, and NF-kBp65 in B lymphocytes of Mayan women with SLE. One hundred patients with SLE and 100 healthy controls, all of them Mayan women, were included. TLR-7 was analyzed on B and T lymphocytes, and MyD88 and NF-kB only in B lymphocytes. Serum INF-α level was evaluated by ELISA. Significant expression (p < 0.0001) of TLR-7 in B and T lymphocytes and serum IFN-α increased (p = 0.034) was observed in patients. MyD88 and NF-kBp65 were also increased in B lymphocytes of patients. TLR-7 and NF-kBp65 expression correlated, but no correlation with INF-α and disease activity was detected. Data support the role of TLR-7 and signal proteins in the pathogenesis of SLE in the Mayan population of Yucatán.
Highlights
Systemic lupus erythematosus (SLE) is an autoimmune disease of connective tissue characterized by B lymphocytes hyperactivity and autoantibodies against nuclear self-antigens
Diagnosis was established according to the American College of Rheumatology (ACR) criteria [36], and disease activity was evaluated by SLEDAI score [37]
The relative fluorescence intensity (rFI) of Toll-like receptors (TLRs)-7 was significantly higher in B lymphocytes of patients, but no difference was found between patients and controls (p = 0.1882) (Figure 1B)
Summary
Systemic lupus erythematosus (SLE) is an autoimmune disease of connective tissue characterized by B lymphocytes hyperactivity and autoantibodies against nuclear self-antigens. The SLE pathogenesis is yet unknown but several genetic, hormonal, and environmental factors are contributing to its development [1,2,3,4]. The incidence of SLE patients varies according to the population studied [5, 6]. It has been reported that the prevalence of SLE in Yucatán (0.7%) is slightly higher than the national prevalence (0.6%) [8, 9], but immune studies have not been conducted in the Mayan population. Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease involving multiple organs. It is currently accepted that several genetic, environmental, and hormonal factors are contributing to its development. Its activation induces intracellular signal with attraction of MyD88 and NF-kBp65, leading to IFN-α synthesis which correlate with disease activity
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