Expression of TK1 in the breast carcinoma and its relationship with Ki67

Abstract

Objective To explore the expression of TK1 in breast carcinoma and discuss its significance of carcinogenesis and progression in breast carcinoma and its relationship with Ki67. Method Using immunohistochemistry methods of SABC and S-P to detect the expression of TK1 and Ki67 in 89 cases of breast carcinoma tissue. Results Positive rate of TK1 in the breast carcinoma was 69.7% (62/89), and the expression of TK1 was significantly associated with lymph node metastasis, TNM stage and histological grade (P 0.05). The expression of TK1 was not significantly correlated with Ki67 in the breast carcinoma (P>0.05). Conclusions Expression of TK1 is associated with carcinogenesis and progression, and it is a poor prognostic marker of breast carcinoma. TK1 and Ki67 are the indicators of cellular growth independently. Key words: Breast neoplasms; Immunohistochemistry; TK1; Ki67