Expression of Thyroid Hormone Receptor-α in the Growth and Development of the Sea Bream (Sparus Aurata)

Lynda Llewellyn,Vimi P. Ramsurn,Deborah M. Power,Trevor Wigham,Glen E. Sweeney

doi:10.1007/978-1-4757-5983-9_23

Expression of Thyroid Hormone Receptor-α in the Growth and Development of the Sea Bream (Sparus Aurata)

Lynda Llewellyn, Vimi P. Ramsurn + Show 3 more

https://doi.org/10.1007/978-1-4757-5983-9_23

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Publication Date: Jan 1, 1998

Affiliation: University of Wales, University of Algarve

#Thyroid Hormones #Thyroid Hormones Deficiency + Show 8 more

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Abstract

Thyroid hormones (THs) play a number of roles in vertebrate organisms. In mammals, in addition to influencing basic metabolic rate, THs affect prenatal and post-natal development, with transgenic mice lacking the thyroid hormone receptor (TR)-α dying within a few weeks of birth, apparently due to an inability to complete some of the maturation processes required for survival in the post-weaning period (Fraichard et al., 1997). Additionally, TH deficiency during differentiation causes a number of abnormalities including neurological and skeletal defects.

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