Abstract
BackgroundExtranodal T/NK cell lymphomas possess distinctive clinico-pathological characteristics: they are angiocentric, exhibit extensive necrosis. Prognosis is poor in the short term. The objective is to explore the expression of different MMPs in the cells and stroma which are around of the blood vessels damaged and their correlation with clinico-pathological parameters.Patients and methodsTwenty cases of this type of lymphomas were studied and collected patient clinical data. The expressions of MMP-1, 2, 3, 9, 11, 13 and TIMP-1, 2 were studied by immunohistochemistry. Ultrastructural studies were performed in two cases. Statistical analysis was done with Fisher's exact test, Chi2 test.ResultsOf the 20 patients, 13 were men with median age of 43 years. In 13 patients the primary tumor was localized in the nasal cavity. Treatment was combined chemotherapy and radiotherapy in 60%. The 55% advanced clinical stages, 70% died from the disease. There were neoplastic cell and peritumoral fibroblasts positivity to MMP-1 and MMP-11 in most of the cases. The MMPs-2, 3 and 9 were expressed in neoplastic cell between 30 to 65%of the cases. TIMP-1 was presented mainly in the epithelium and TIMP-2 was poor expressed of the all cases.ConclusionThere were no statistical significance between the different enzymes used and the clinical parameters, besides status and survival of the patients. It is necessary to study more enzymes and focus them to quantify and determine their activity, in order to have a better correlation with histological features in this type of neoplasm.
Highlights
Extranodal T/natural killer (T/NK) cell lymphomas possess distinctive clinico-pathological characteristics: they are angiocentric, exhibit extensive necrosis
In 13 cases (65%) the primary tumor was localized in the nasal cavity, in four patients it was localized in the palate and in three in the nasopharynx (Fig. 1)
Regarding the expression of inhibitors, TIMP-1 was found statistically significant difference regarding the proportion of cases that expressed MMP-9, likewise observed for TIMP2 regarding MMP-2
Summary
Extranodal T/NK cell lymphomas possess distinctive clinico-pathological characteristics: they are angiocentric, exhibit extensive necrosis. Nasal-type extranodal T/natural killer (T/NK) cell lymphomas represent a distinctive clinico-pathological entity, characterized by progressive destruction. This type of lymphoma generally originates in the nasal cavity, the palate or midfacial region, and its main characteristic is angioinvasion and angiodestruction, accompanied by extensive areas of necrosis [1,2,3,4]. Nasal type extraganglionary T/NK cell lymphomas have a characteristic geographical distribution They show predominance in Asian and Latin American countries, including Mexico [7,8,9,10], and rarely appear in Caucasian countries. This type of geographical distribution is closely associated to a high incidence of infection by EBV, as has been extensively reported [1,9,12,13]
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