Abstract
Background It is well known that cancer cells display increased glucose uptake and consumption [1]. In a rate-limiting step for glucose metabolism, the glucose transporter (GLUT) proteins facilitate glucose uptake across the plasma membrane. In human cells, 14 different GLUT (1-14) isoforms have been discovered. Of these, GLUT1, 3 and 4 have been extensively studied while the more recently discovered GLUT12 has high relevance to cancer [2]. A comprehensive view of the basal levels of GLUT proteins in cancer is lacking and the exact role of these proteins in cancer cell metabolism is unclear. The present study examined GLUT expression in a number of human cancer cell lines.
Highlights
It is well known that cancer cells display increased glucose uptake and consumption [1]
The expression of GLUT1 and GLUT3 was immunohistochemically examined in tumors from Balb/c nude mice xenografted with A549, H1299 and PC-3 human cancer cells
GLUT1, GLUT3, GLUT4 and GLUT12 mRNA was detected at various levels in all cells examined
Summary
It is well known that cancer cells display increased glucose uptake and consumption [1]. In a rate-limiting step for glucose metabolism, the glucose transporter (GLUT) proteins facilitate glucose uptake across the plasma membrane. 14 different GLUT (1-14) isoforms have been discovered. GLUT1, 3 and 4 have been extensively studied while the more recently discovered GLUT12 has high relevance to cancer [2]. A comprehensive view of the basal levels of GLUT proteins in cancer is lacking and the exact role of these proteins in cancer cell metabolism is unclear. The present study examined GLUT expression in a number of human cancer cell lines
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