Abstract
Epstein–Barr virus-induced gene 2 (EBI2) is a recently de-orphanized G-protein coupled receptor. Expression of EBI2, as well as generation of its most potent ligand, 7alpha,25-dihydroxycholesterol (7alpha-OHC) play important roles in positioning and function of B cells and dendritic cells (DCs). However, up to now only little is known about the expression and function of EBI2 in T cells. Using a novel reporter-knockin/knockout (KO) mouse model, we found that EBI2 expression is highly regulated in T cells.
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