Abstract
Wound healing is a highly coordinated process involving clot formation, inflammatory reaction, immune response, and tissue remodeling. Transforming growth factor beta (TGF-β), epidermal growth factor (EGF), and platelet-derived growth factor (PDGF) are known to be active during different phases of wound repair. Nasal secretions were obtained from eight patients 1, 2, and 3 weeks after functional endoscopic sinus surgery (FESS) and compared to 13 controls. Nasal fluid was collected by sinus packing and was analyzed by enzyme-linked immunosorbent assay (ELISA) for TGF-β1, TGF-β2, EGF, and PDGF. Comparing patients 1 week after surgery with control subjects, a significant increase in the concentrations of TGF-β1, TGF-β2, and PDGF in nasal secretions could be demonstrated (p<0.001). At 2 and 3 weeks after surgery, decreasing amounts of these growth factors were found, nearly reaching normal conditions again. In contrast, EGF concentrations in nasal fluids tended to be decreased in patients 1 week after FESS compared to controls, with this level persisting during 3 weeks of mucosal healing. This is the first study proposing a follow-up method for nasal and sinus mucosa healing after surgery to determine cytokine secretion profiles.
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